ROME — In his strongest words yet, Pope Leo XIV on Saturday denounced the “delusion of omnipotence” that is fueling the U.S.-Israel war in Iran and demanded political leaders stop and negotiate peace.

Leo presided over an evening prayer service in St. Peter’s Basilica on the same day the United States and Iran began face-to-face negotiations in Pakistan and as a fragile ceasefire held.

History’s first U.S.-born pope didn’t mention the United States or President Donald Trump in his prayer, which was planned before the talks were announced. But Leo’s tone and message appeared directed at Trump and U.S. officials, who have boasted of U.S. military superiority and justified the war in religious terms.

“Enough of the idolatry of self and money!” Leo said. “Enough of the display of power! Enough of war!”

In the basilica pews was the archbishop of Tehran, Belgian Cardinal Dominique Joseph Mathieu. The U.S. was represented in the diplomatic corps by its deputy chief of mission, Laura Hochla, the U.S. Embassy said.

In the first weeks of the war, the Chicago-born Leo was initially reluctant to publicly condemn the violence and limited his comments to muted appeals for peace and dialogue. But Leo stepped up his criticism starting on Palm Sunday. And this week, he said Trump’s threat to annihilate Iranian civilization was “truly unacceptable” and called for dialogue to prevail.

On Saturday, Leo called for all people of good will to pray for peace and demand an end to war from their political leaders. The evening vigil in Rome, which featured Scripture readings and meditative recitation of the Rosary prayers, was taking place as simultaneous local prayer services were being held in the U.S. and beyond.

Praying for peace, Leo said, was a way to “break the demonic cycle of evil” to build instead the Kingdom of God where there are no swords, drones or “unjust profit.”

“It is here that we find a bulwark against that delusion of omnipotence that surrounds us and is becoming increasingly unpredictable and aggressive,” he said. “Even the holy Name of God, the God of life, is being dragged into discourses of death.”

Leaders have used religion to justify their actions in the war. U.S. officials and especially Defense Secretary Pete Hegseth have invoked their Christian faith to cast the U.S. as a Christian nation trying to vanquish its foes.

Leo has said God doesn’t bless any war, and certainly not those who drop bombs.

Leo presided over the service sitting off to the side of the altar on a white throne, wearing his formal red cape and liturgical stole and praying with a Rosary in his hands. Many of the priests and nuns in the pews fingered Rosary beads as the “Our Father” and “Hail Mary” prayers were recited.

The Vatican is particularly concerned about the spillover of Israel’s war against Hezbollah in Lebanon, given the plight of Christian communities in the south.

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