Venezuela’s former first lady, Cilia Flores de Maduro, has asked a judge to release her from federal detention in the United States, citing a worsening heart condition.

In an application for pre-trial release on Wednesday, her legal team asked for the court to allow Flores to await trial under home confinement in Manhattan.

It described her declining health since US military operation on January 3 that resulted in her abduction from Caracas and imprisonment in New York, as well as that of her husband, former Venezuelan President Nicolas Maduro.

“Prior to the United States’ military invasion of Venezuela, Ms. Flores de Maduro was physically healthy and took no ongoing medication, other than a monthly injection to help control her mitral valve prolapse,” the legal filing said.

“Now she is prescribed four medications, maintains nitroglycerin by her side in the event of a potential heart attack, and grapples with the continued medical advice suggesting coronary exploration and surgery.”

Flores was a prominent figure in her husband’s government, serving as first lady since his inauguration in 2013.

Prior to Maduro’s first inauguration, she was also a leading member of the United Socialist Party of Venezuela (PSUV), the country’s dominant political movement, leading the National Assembly for more than four years.

But Maduro had long clashed with the administration of US President Donald Trump, who accused Venezuela of sending drug-traffickers into the US. Both Maduro and Flores have also faced allegations of participating in human rights abuses, including the violent suppression of political dissent.

After launching a one-day military operation to abduct Maduro and Flores, the Trump administration charged them both with drug- and weapons-related charges. They are currently awaiting trial in New York City.

But Flores’s health has been in doubt since her forced removal from Venezuela, according to her legal team.

After consulting outside medical experts, Flores’s lawyers said they believe she may have suffered a minor heart attack on July 29 while in US custody.

They also questioned whether she was receiving the appropriate medical care for her mitral valve prolapse, a condition affecting one of the heart’s valves.

Since her imprisonment, her lawyers said Flores has not received the monthly injection she needs to manage the condition.

Instead, she has reportedly been prescribed baby aspirin, a statin, diltiazem and nitroglycerin to use when she experiences chest pain.

Doctors have recommended that she undergo a cardiac procedure, which could result in additional heart operations. If she undergoes such treatment, Flores “will need adequate time to recover from any procedures in a setting conducive to restoring her health”, her lawyers said.

Thursday’s filing acknowledges that Flores does not “dispute that she has received excellent care” from medical professionals. But it argues that “a detention centre lacks the conditions needed for such a recovery”.

Her lawyers proposed moving Flores from the Metropolitan Detention Center in Brooklyn to a residence within the Manhattan federal court district, where she and Maduro are due to go on trial next June.

Under home detention, Flores would be subject to round-the-clock armed monitoring, with visits restricted to people approved by the court and federal prosecutors. Her home would also be monitored by video and her phone calls recorded, according to the filing.

Judge Alvin K Hellerstein has yet to rule on the application.

Flores, 69, and Maduro, 63, have been held in US custody since the January raid on their home in Caracas. Both have pleaded not guilty to the charges of participating in a conspiracy to traffic cocaine into the US.