Novak Djokovic suffered from punishing heat and humidity on Saturday but made a match of it before falling 2-6, 6-4, 6-4 to Thiago Tirante in what could be the Serb’s last appearance at the ATP-WTA Cincinnati Masters.

The second-round battle lasted for more than two and a half hours, and it proved too much for the 24-time Grand Slam champion, who was playing his first match since he lost to Jannik Sinner in the Wimbledon semifinals more than a month ago.

Top-seeded Alexander Zverev, the French Open champion who fell to Sinner in the Wimbledon final, was more fortunate, squeezing out an opening 3-6, 6-3, 6-3 victory over Cameron Norrie in a match that took two hours and 45 minutes and ended at 2:15am.

Britain’s Norrie has now lost all eight of his matches against the German, winner of the Cincinnati title five years ago, who is hoping a return to Ohio will help him shake off an abrupt exit in Canada last week.

Norrie had wrapped up the opening set before Zverev began to find his footing to level the match.

Norrie saved six break points in a 12-minute game to begin the deciding set but was broken twice as Zverev advanced.

“I needed to get a match rhythm,” Zverev said. “The confidence was not there after Canada.

“The first set was not great, but the other two were at a high level, and I’m happy about that.”

Depleted Djokovic

Djokovic, who claimed the last of his three Cincinnati titles in 2023, took the opening set against Argentina’s Tirante with little fuss.

But the sweltering afternoon temperatures took a toll.

“It was a combination of the heat and humidity, all those things,” he said. “Everything involved makes it worse.”

Djokovic won a brutal 18-minute third game of the second, saving four break points over nine deuces. But he was bent over in distress between several points and even dropped to his hands and knees after one particularly gruelling exchange.

Djokovic took a medical timeout after that game, with the physio and then a doctor coming on court to assist with assessments and ice towels.

After Tirante took the second set, both players cooled off in the locker room.

Slightly revived, Djokovic set the pace again in the deciding set. But it all went wrong in the ninth game, when Djokovic saved three break points before getting it wrong on a drop shot to bring up a fourth break chance that his opponent converted.

Tirante clinched the biggest win of his career in the next game as Djokovic again failed to land a drop shot on match point.

The Serb, who must now try to regroup before the US Open starts on August 30, admitted he might have played his last match in Cincy.

“It looks like I won’t be back, unfortunately, to play here,” he said.

Tirante called the win the best of his career.

“I managed the nerves of playing a legend like Novak. It was all so much pressure.”

‘Focused’ Eala advances

In the WTA draw, Philippines sensation Alexandra Eala advanced to the third round 6-1, 3-0 as injured Elena-Gabriela Ruse retired from their match during a weather delay.

The Romanian had received treatment on her right ankle just before play was halted by a thunderstorm, Ruse pulling the plug during the delay.

Eala, the emerging WTA star who captured her first WTA title in Washington, DC, this month, will next play ninth-seeded American Amanda Anisimova, who beat Turk Zeynep Sonmez 6-2, 6-3.

“I was playing well and feeling really focused,” Eala said. “I tried to stay in the zone.”

“A retirement is not the way you want to end a match,” she added. “Injuries are not fun.”

Roland Garros finalist Maja Chwalinska advanced 6-2, 6-2 over Spain’s Cristina Bucsa.

Wimbledon winner Linda Noskova followed suit with her 6-3, 6-3 defeat of Britain’s Katie Boulter.

There was heartbreak for Payton Stearns, who grew up just blocks from the tennis centre. She lost 7-6 (9/7), 1-6, 7-5 to Dane Clara Tauson, who played through back pain but rallied from 4-1 down in the final set to win.