Ohio’s primary elections on Tuesday have set the stage for what is anticipated to be one of the nation’s most costly U.S. Senate contests this year, alongside a high-stakes gubernatorial battle.

Democrats are pinning their hopes on former Senator Sherrod Brown, who easily secured his party’s nomination, to unseat Republican Senator Jon Husted in November. Brown’s established popularity among voters is seen as key to flipping the seat, a critical objective for Democrats aiming to gain control of the chamber during a challenging midterm cycle.

The Republican effort to defend Husted, who ran unopposed in his primary, is already backed by a substantial $79 million pledge from the Senate Leadership Fund, a prominent GOP super PAC.

Meanwhile, biotech entrepreneur Vivek Ramaswamy clinched the Republican nomination for governor, overcoming a minor challenger. He will now face Democrat Amy Acton, the state’s former health director from the COVID-era, in the general election, as Republicans seek to retain the governor’s office.

“We’re going to revive that American Dream in Ohio once again, with lower costs, bigger paychecks and better schools for all Ohioans,” Ramaswamy said in a statement Tuesday evening.

A newcomer to state politics, Ramaswamy aggressively positioned himself for the job early with the help of endorsements from President Donald Trump and the state Republican Party.

Trump’s endorsement continues to carry weight in Ohio, which favored him three times for president, but Ramaswamy could face headwinds amid the president’s lagging popularity over the war in Iran and the rising cost of living.

Acton, a physician who was unopposed in her primary, has a well-known public profile and robust fundraising. That has Democrats hopeful she can get the party back in the governor’s office for the first time in 20 years.

Ramaswamy, a 2024 GOP primary presidential candidate, swept onto the state’s political scene early last year as a mad shuffle was taking place. Then-Sen. JD Vance was ascending to the vice presidency and front-running gubernatorial candidate Jon Husted was being appointed to replace him in Washington.

That opened a window of opportunity at the top of Republicans’ statewide ticket.

Every statewide executive office was open this year due to term limits, but the governor’s race captured the bulk of the attention.

Primary sets up marquee fall matchups for governor, Senate

Though he is a newcomer in state politics, Ramaswamy’s national profile, tech industry connections and proximity to Trump landed him the Ohio Republican Party’s endorsement. With it, he cleared a prospective field that included the sitting state attorney general, state treasurer and lieutenant governor.

But Democrats also see opportunity with the open governors seat, even as the state, a former bellwether, has tipped convincingly toward Republicans during the Trump era. The president’s lagging approval ratings on the economy and dissatisfaction over the war in Iran are contributing to a competitive contest.

Acton, a physician and public health expert, emerged as their choice. She became a household name across Ohio in the early days of the COVID-19 pandemic as she stood alongside Republican Gov. Mike DeWine during daily coronavirus broadcasts. Her comforting presence during the crisis made her a beloved figure with many Ohioans.

“I just think she’s real,” said Aaron Weiner, a Cincinnati real estate agent who voted for Acton. “She has had struggles, so I think she can empathize with people who are struggling to get ahead.”

But the administration’s aggressive actions — including shuttering businesses, closing schools and canceling an election — also earned Acton plenty of enemies and made her the occasional target of people upset about pandemic policies, with some armed protesters showing up outside her home.

Ramaswamy’s campaign sought to capitalize on the lingering anger over pandemic restrictions with attacks on Acton’s role early in the crisis. Ramaswamy was advising the lieutenant governor at the time — Husted — on virus-related economic issues and he founded a company that profited off its role developing vaccines.

Acton was unopposed in the Democratic primary, while Ramaswamy faced a long-shot challenge from Casey Putsch. The engineer and car designer is a YouTube provocateur who trolled Ramaswamy incessantly over his Indian heritage and Hindu faith and painted him as an out-of-touch billionaire “tech bro.”

Cincinnati voter Paul Mussman, who cast his ballot for Ramaswamy, said he considers it an asset that he is a relative newcomer to politics.

Ramaswamy would look at issues “in a fresh way and not based on what their party affiliation is,” Mussman said.

Husted was unopposed in the GOP primary for Senate, a special election to fill the remainder of the six-year Senate term Vance won in 2022. Husted’s opponent will be Democrat Sherrod Brown, a former three-term senator who lost a reelection bid against Republican Bernie Moreno in 2024, a contest where spending hit $500 million. Brown faced a minor primary challenge from first-time candidate Ron Kincaid.

Early voting began April 7 under some new election laws, including citizenship checks and elimination of the four-day grace period for receiving mailed ballots. There have been no reports so far of any widespread problems for voters related to the changes.

Republicans see some Democratic-held House seats as vulnerable

In the wake of a new round of redistricting that slightly favored Republicans, the state also had numerous partisan congressional primaries.

The most heated GOP primary was in the Toledo area’s 9th District for the chance to take on Democratic U.S. Rep. Marcy Kaptur, the longest-serving woman in Congress.

The five-way contest included former state Rep. Derek Merrin, whom Kaptur defeated by less than a percentage point in 2024, as well as an Air National Guard veteran, a healthcare industry worker, a sitting state representative and the former deputy director of U.S. Immigration and Customs Enforcement, Madison Sheahan.

In Democratic U.S. Rep. Greg Landsman’s Cincinnati-area district, which his party considers a “must-hold,” the three-way Republican primary included Eric Conroy, a CIA and Air Force veteran who was endorsed by Trump, Vance and Moreno.

Landsman also faced a primary challenge from Damon Lynch IV, the grandson of a prominent civil rights leader. Lynch criticized Landsman for his initial vote against a war powers resolution on the war in Iran, which Landsman later followed up with a favorable vote.

In the Akron area’s 13th District, five Republicans including business owner Neil Patel, a 2022 U.S. Senate candidate, were vying for the opportunity to face Democratic U.S. Rep. Emilia Sykes.

Democrats think new House maps give them a shot to regain seats

As a Trump-backed national effort to remake congressional maps in Republicans’ favor was underway, Ohio Democrats took a could-have-been-worse approach and passed the map they were given unanimously.

Now party candidates are crowding congressional primaries across the state for the chance to take on sitting Republican representatives, who hold 10 of Ohio’s 15 seats.

The newly redrawn 7th District in the Cleveland area attracted eight Democrats hoping to challenge Republican U.S. Rep. Max Miller, a former senior Trump adviser, in November. Among them was former Cuyahoga County Executive Ed FitzGerald, the Democratic nominee for governor in 2014.

In northeast Ohio’s 14th District, former state Supreme Court Justice William O’Neill was among three Democrats seeking to take on Republican U.S. Rep. Dave Joyce. Joyce also has two primary challengers.

Meanwhile six Democrats were on the ballot in the Dayton-area 10th District of Republican U.S. Rep. Mike Turner. There were seven in GOP U.S. Rep. Michael Rulli’s 6th District along the Ohio River and five in the 5th District of Republican U.S. Rep. Bob Latta.