The latest attack brings the death toll from US military boat strikes to at least 235 from 70 maritime strikes across the region.

The United States has conducted another strike on an alleged drug trafficking boat in the Caribbean, killing four, according to the US military.

US Southern Command said late Sunday that it struck alleged drug traffickers operating along “established narco-trafficking routes” in the eastern Pacific and Caribbean, following its standard reporting pattern for military operations of suspected cartels across the multinational maritime zones.

The latest attack brings the death toll from US military boat strikes to at least 235 deaths across 70 attacks, since the administration of US President Donald Trump first launched its counter-narcoterrorism campaign, termed Operation Southern Spear, in September of last year.

At the time, Trump characterised the fight against cartels in Latin America as an active “armed conflict” while defending the strikes as a necessary escalation to curb illicit drug trafficking and reduce fatal US overdoses.

The move comes as United Nations experts warn that the strikes violate international law and could amount to crimes against humanity.

Despite releasing footage on X showing the explosion that destroyed the moving vessel, the US military has offered no evidence that the targeted boat was ferrying drugs.

The Trump administration has been actively seeking regional security agreements across Latin America to expand joint military operations against what it has designated as criminal cartels.  The deals come under the US-led Shield of the Americas coalition, launched in March. The president has pledged the undertaking will use “unmatched military might” to dismantle drug cartels while simultaneously countering Chinese economic influence in the Western Hemisphere.

During a visit to Panama in August, Defense Secretary Pete Hegseth announced that Colombia, Guatemala and Honduras had agreed to joint counter-crime military operations on their soil, a statement Guatemala quickly disputed to clarify its sovereignty and boundaries within the 19-member alliance.